The Fellowship Program in Resuscitation Medicine prepares future physician-scientists for careers of discovery in the science and clinical implementation of emergency cardiovascular care.
This training program encourages course work towards a masters degree in a translational or clinical science area, with bench or clinical research that will be used to apply for future K08 or K23 Career Development Award funding.
Clinical and laboratory projects seek to improve our understanding of impaired heart function following conditions of sudden hypotensive shock as occurs following cardiac arrest and severe hemorrhagic shock.
These are leading causes of death in the elderly and young adults, and many patients die within hours after resuscitation (e.g. with CPR or blood transfusion) due to severe cardiovascular dysfunction of unclear etiology. This lethal dysfunction may result from profound changes in heart metabolism and ion channels, sarcomere protein interactions, pulmonary vascular resistance, and systemic microvascular endothelial integrity.
Therapeutic strategies are being identified that affect time-sensitive changes seen in oxidant stress and inflammation, and determine heart function, resuscitation success and survival. Promising strategies recently identified include the use of nitric oxide or other gasses to inhibit mitochondrial oxidant generation, and blocking early identified initiators of innate immune response.
In the laboratory, we combine complementary in vivoand in vitro models of resuscitation that allow for both pharmacologic and genetic approaches of inquiry. Online measurements of cardiomyocyte and heart function are linked to indicators of oxidant stress, mitochondrial function, and the induction of inflammatory responses as measured by protein, message and micro-RNA alterations.
We combine these imaging and molecular techniques to uniquely examine and treat the heart dysfunction seen within a body exposed to sudden shock and resuscitation.
Advanced Resuscitation Medicine Director
Terry Vanden Hoek, MD
Professor and Chair